Sentence examples for molecular abnormalities include from inspiring English sources
Molecular abnormalities include JAK2 V617F [Mendelian Inheritance in Man (MIM) reference 614521], a mutation found in 50% of ET patients (Kralovics et al, 2005).
Molecular abnormalities include expression of oncogenes, such as Ki-ras, c- myc, c- erb-B-2 and bcl-2, and tumour suppressor genes, such as p53, Rb and FHIT (fragile histidine triad) in lung cancer (Otterson et al, 1998; Salgia and Skarin, 1998).
The complex process that drives the development of leukemia could rise from several clonal molecular abnormalities, including copy number gains and losses in the genome leading to activation of proto-oncogenes and silencing (or deletion) of tumor suppressor genes, respectively [3], [4].
Endometriosis shows molecular abnormalities, including the activation of the oncogenetic pathway [ 23] that allows the endometrial tissue to implant, survive, and invade the ovarian and peritoneal tissue.
The process of tumorigenesis needs to be initiated and promoted by molecular abnormalities including oncogenes activation and tumor suppressor genes (TSGs) inactivation [ 2].
Overall, our mutational annotations suggest that the pathological consequences of dysfunctional DRS could stem from various molecular abnormalities including defective dimerization, incompetent tRNA binding and structural instability.
In fact, for several actionable molecular abnormalities, including ALK rearrangements, the median age of onset may be several years younger than for the general lung cancer population (Weickhardt and Camidge, 2011).
The precise molecular mechanisms underlying the pathogenesis of iron-overload-related diabetes have not been identified but the initial glucose abnormalities include insulin resistance and hyperinsulinaemia, followed by impaired insulin secretion [ 2].
These abnormalities include anaemia, bleeding and granulocyte and platelet dysfunction.
Metabolic abnormalities include insulin resistance and dyslipidemia.
Skeletal abnormalities include three subcategories: malformations, injuries, and abnormalities of unknown origin (Table 2).
