Sentence examples for molecular abnormalities in from inspiring English sources
However, identification of the molecular abnormalities in cancer, in particular the key proteins involved in abnormal cell growth, has resulted in development of various signal transduction inhibitor drugs as new treatment strategies against the disease.
Dent, J.A., Berkowitz, S.D., Ware, J., Kasper, C.K. & Ruggeri, Z.M. Identification of a cleavage site directing the immunochemical detection of molecular abnormalities in type IIA von Willebrand factor.
Large chromosomal deletions are among the most common molecular abnormalities in cancer, yet the identification of relevant genes has proven difficult.
Prescription of personalized therapies in non-small cell lung carcinoma is mainly based on histological subtype and molecular abnormalities in tumor specimens.
The expanding knowledge of the underlying molecular abnormalities in this once very poorly understood cancer should allow for increasingly rational clinical trial design and improved patient outcomes.
To better understand the molecular abnormalities in small bowel adenocarcinoma (SBA), we characterised a number of candidate oncogenic pathways and the immunophenotype of this rare cancer.Tissue microarrays were constructed from tumour samples from 54 patients with all stages of the disease.
Amyloid fibril protein in familial amyloidotic polyneuropathy, Portuguese type: definition of molecular abnormality in transthyretin (prealbumin).
As long as researchers understand the crucial molecular abnormality in a cancer, design a drug to fix that problem, and use it in only in patients who have that molecular anomaly, then such targeted therapies can be effective.The need for combinationsIn general, the academic community and pharmaceutical companies agree with this assessment.
EML4-ALK fusion was recently identified as a novel molecular abnormality in about 5% of lung adenocarcinomas 7, 8.
Only the most malignant tumours, known as glioblastoma multiforme, had more than one molecular abnormality in the same tumour.
Blocking cell death promotes neoplastic transformation [ 10]. p53 Mutations in the p53 gene are a common molecular abnormality in breast cancer [ 30, 31].
