Sentence examples for molecular abnormalities are from inspiring English sources

The most frequent molecular abnormalities are alterations to the tumor suppressor, p53 (Ahuja et al. 1989).

Since molecular abnormalities are often found in histologically normal-appearing tissue adjacent to tumor tissue, we chose to obtain control tissues from endoscopic biopsy samples from normal, cancer-free volunteers.

Many molecular abnormalities are identified in osteosarcomas giving the cancer cells some particular characteristics: proliferative signals (PDGFR, IGFR, c-KIT), resistance to retroaction signals (p53, RB), resistance to cell death (ERK, Bcl-2), angiogenesis (VEGFR, PDGFR), resistance to immune destruction (IFN) [ 12].

Risk stratification, based on cytogenetics and molecular abnormalities, was used to categorize patients into three groups: favorable-, intermediand-, and unfavorable-risk groups [4].

Recently several molecular abnormalities were reported to associate with sensitivity or resistance to EGFR inhibitors, including somatic mutations in the EGFR tyrosine kinase domain, EGFR gene amplification, KRAS mutation, and MET amplification [14], [15], [16], [17].

If one or several molecular abnormalities were identified, then patients were randomised.

121 Subsequently, molecular abnormalities were investigated in 11 patients from nine unrelated families.

Reports of leukaemia cell cytogenetic and molecular abnormalities were obtained from the treating COG institution.

The clinical impact of these different genetic and molecular abnormalities is 3-fold.

The diagnosis of refractory cytopenia in July 2010 without genetic and molecular abnormalities was followed by bone marrow transplantation (BMT).

Druggable molecular abnormalities were defined in our study as molecular abnormalities that were thought to be relevant biomarkers of efficacy for 11 MTAs already on the market in France.