Sentence examples for molecular abnormalities and from inspiring English sources
As knowledge of the molecular abnormalities and dysregulated cellular processes contributing to the pathogenesis and progression of lung cancer has been acquired, intense interest has been directed at developing agents that target these abnormalities.
Due to the heterogeneity of the detected molecular abnormalities and the low number of pediatric patients, Gustave Roussy with the ITCC network has launched a platform trial of 10 phase I/II parallel arms.
Our results suggest that further studies on the prognostic potential of the combination of molecular abnormalities and interim 18F-FLT PET/CT results are warranted.
This idea is reinforced by the anomalous response of H292, which suggests these cells are driven by very different molecular abnormalities, and that their TKI-induced cell cycle arrest is mechanistically distinct from that seen in the other lines.
In all cases, however, the OLCs showed morphological and molecular abnormalities and were not proved to be functional.
Out of 202 CRCs, thirty-four (17%) were free from molecular abnormalities and with no association with M+ vs M− tumours.
In all cases, however, the OLCs inside these structures showed morphological and molecular abnormality and were not proved to be functional.
Detailed reports on leukaemia cell cytogenetics and molecular abnormalities were obtained for cases and included leukaemia subtype (ALL, AML) and MLL gene translocation status (MLL+, MLL−, undetermined).
In this issue, Devouassoux-Shisheboran and Genestie [7] report the newly described molecular abnormalities of EOC and the 2014 World Health Organization (WHO) classification based on tumor morphology.
The discovery of recurrent molecular abnormalities, like JAK2V617F and MPLW515L/K mutations [1], has reinforced the Dameshek's vision that these disorders have a common pathogenetic mechanism and presumably belong to an unique disease process [2].
Genetic analysis revealed various molecular abnormalities (Table 1 and Fig. 2).
