Molecular abnormalities commence in normal-appearing epithelium in chronically inflamed gallbladders.
Matching treatment to molecular abnormalities appears as a promising strategy.
Most cancers have multiple genetic alterations and molecular abnormalities.
Advances in genome-sequencing technologies and powerful analytics are increasingly being used to pinpoint errant genes and other molecular abnormalities that drive cancer's growth.
Molecular abnormalities have also been identified in tumors other than adenocarcinoma (squamous and small cell carcinoma).
Here we show that neural-targeted ablation of SPL and the consequent accumulation of S1P and sphingosine leads to behavioural, morphological, physiological and molecular abnormalities.
Wistuba, I. I., Miquel, J. F., Gazdar, A. F. & Albores-Saavedra, J. Gallbladder adenomas have molecular abnormalities different from those present in gallbladder carcinomas.
Meador-Woodruff, J. H., Clinton, S. M., Beneyto, M. & McCullumsmith, R. E. Molecular abnormalities of the glutamate synapse in the thalamus in schizophrenia.
Dent, J.A., Berkowitz, S.D., Ware, J., Kasper, C.K. & Ruggeri, Z.M. Identification of a cleavage site directing the immunochemical detection of molecular abnormalities in type IIA von Willebrand factor.
Now, instead of treating all leukemia patients the same way, we had different drug options depending on a patient's genetic and molecular abnormalities.
We then tested whether the aldose reductase inhibitor sorbinil and aspirin, which have different mechanisms of action, prevented common molecular abnormalities induced by diabetes.
