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We calculated molar sums of the three DEHP metabolites to obtain a summary measure of DEHP using a previously reported technique (Wolff et al. 2008).
We determined the molar sums of the dimethyl-containing and diethyl-containing metabolites; their geometric mean concentrations were 49.4 and 10.5 nmol/L, respectively, and their 95th percentiles were 583 and 108 nmol/L, respectively.
Calculated molar sums of "low-molecular-weight phthalates" or "high-molecular-weight phthalates" or the sum of all phthalates also were not significantly associated with any hormones or semen quality variables (results not shown).
Molar sums of the metabolites of low-molecular-weight phthalates (MEP, MiBP, and MnBP) and metabolites of high-molecular-weight phthalates (MBzP, MCPP, and DEHP and DiNP metabolites), and the molar sum of all phthalate metabolites, were calculated as described by Wolff et al. (2010).
We calculated the molar sums of individual metabolites (in micromoles per liter) of DEHP because they occur from the same parent phthalate, and also of HMWP and LMWP, as they represent similar sources of exposure and they are moderately to highly correlated (ΣDEHPm, ΣHMWPm, and ΣLMWPm, hereafter) (Valvi et al. 2015).
Similar(54)
The lines depict the relationship for the ratio between measured and BLM calculated toxicity (measured LC50, EC50) as well as the ratio between the molar sum of metals (Fe, Al) and DOC in four lakes.
Compound and optical variables was also investigated and it was found that the molar sum of Al and Fe was a better predictor of bioassay toxicity for both test species than Fe was alone and CSF appeared to correlate strongly with bioassay toxicity (Fig. 2).
Total DAPs consisted of the molar sum of total DMs and total DEs.
Findings were weaker for urinary MEHHP, MEOHP, and the molar sum of the three DEHP metabolites.
Furthermore, the molar sum of 3ADON, 15ADON, and DON was higher than the initial sum of these toxins before hydrolysis.
Similarly, a molar sum of the paraben metabolites was created (paraben sum) expressed as propyl paraben (molecular weight 180.2).
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