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Freshly distilled methyl acetate (8.6 mL, 0.11 mol) was added.
After 1 h, ethanolamine (7.49 ml, 0.125 mol) was added dropwise to the reaction solution.
1-Bromooctane (8.7 mL, 0.05 mol) was added dropwise through a drop funnel.
To this solution 5 (6.3 kg, 10.25 mol) was added under vigorous stirring.
After stirring for 15 min, NaOH (13.9 g, 0.35 mol) was added at room temperature.
To boiling solution of compounds 10a b (0.01 mol) in ethanolic potassium hydroxide (30 mL, 10%), thiourea (0.01 mol) was added.
Thep-hydroxybenzaldehyde (3.0744 g, 0.0252 mol) and benzaldehyde (8.0242 g, 0.0757 mol) were added to 300 mL of propionic acid.
To this mixture, 4 mL of pyridine (0.05 mol) was added and shaken well for 2 hours.
To a vigorously stirred solution of DMF (2.9 mL) at 0°C, POCl3 (2.8 mL, 0.030 mol) was added dropwise.
Thiosemicarbazide (4.56 g, 0.05 mol) was added and the mixture was heated and reflux for 5 h.
The 2,4,6-trimethylbenzoyl chloride (0.025 mol) was added dropwise to the mixture over a period of 30 min.
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CEO of Professional Science Editing for Scientists @ prosciediting.com