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Incorporation of a mEG moiety would be a useful and convenient approach to attain high intraocular penetration.

The calculated results reveal that the dye with the incorporation of EDOT moiety would be more beneficial for photocurrent and photovoltage performance.

To remove the undesirable CYP3A4 TDI activity, structural modification was focused on the 2,4-difluoroaniline moiety on the basis of the assumption that this moiety would be involved in mechanism-based inhibition of CYP3A4 via oxidative metabolism.

The protein moiety of the conjugate would be expected to enable its adsorption to the interface, and the polysaccharide moiety would be expected to form self-assembled networks, strengthening the interfacial film as a whole.

It is resulted that molecular volume of the amide moiety would be a major factor in inhibitory potency variation of the synthetic amides, where the hydrogen bonding of the amide group could also involve in the activity of the inhibitors.

The hypothesis behind the design of this new radioligand was that the rate of defluorination of the [18F]FE moiety would be reduced through a deuterium isotopic effect since the carbon-deuterium [C-D] bond is generally stronger to break than the carbon-hydrogen [C-H] bond.

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Sufficient lipophilicity imparted by these moieties would be expected to drive these prodrugs into assembling into the hydrophobic core of NPs in an aqueous environment.

This number of SAS-6 moieties would be sufficient for a turn of the SAS-6 spiral to form (4.5 SAS-6 dimers/turn), but not for a complete SAS-6 ring (9 SAS-6 dimers/ring).

9 Also, the conformation of cADPtR, particularly, the spatial positioning of the N1-thioribose and adenine moieties, would be similar to that of cADPR because of the similar sp configuration of the oxygen and sulfur atoms.

This number of SAS-6 moieties would be sufficient for just over one turn of the proposed SAS-6 spiral (Hilbert et al., 2013), but not for a SAS-6 ring (Kitagawa et al., 2011b; Van Breugel et al., 2011; Van Breugel et al., 2014).

The electron density in Figure 5 was fitted using the cyclic hemiacetal form of the HNE moiety, which would be consistent with the NMR data.

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