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Due to the construction principle, the S-layer fusion protein fully retained the self-assembly capability of the S-layer moiety, while the catalytic domain of LamA remained exposed at the outer surface of the formed protein lattice.
Many activities were limited to just one of the seasons; trading and hunting, for instance, could only take place under the authority of the Winter moiety, while the gathering of wild plants was limited to the period of the Summer People's administration.
The insertion of the donor sugar at this position would allow the formation of hydrogen bonds between Glu232 (Asp192 in MgS) and the O6 and O4 oxygens of the glucose/mannose moiety, while the side chains of Asp134 and Lys114 would provide polar contacts with the O3 oxygen, as observed for the structurally equivalent Asp192, Asp100 and Lys76 in MgS.
In PLK1, BI2536 binds to the hinge region through the aminopyrimidine moiety while the dihydropteridine oxygen is involved in water-mediated interactions around the gatekeeper residue Leu130.
MIS12-FRB could be visualized by virtue of a C-terminal FLAG-tagRFP moiety, while the MAD1 proteins could be visualized via an N-terminal eYFP moiety.
This sensitivity to acids is attributed to the sugar moiety, while the nature of the aglycon is more responsible for the instability of glycosides under basic conditions [ 17].
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Starting from Trolox, we have synthetized a library of 226 new chemical entities (Patent WO2014011047 (A1)) by modifying the side chain on the carboxyl moiety while conserving the chromanyl group bearing the antioxidant capacity (Fig. 2a).
The CAR format provides an opportunity to recognize practically any desired target antigen by changing only the corresponding binding moiety while retaining the backbone structure.
The HOMO orbitals for all foldamers have consistently large densities on anthracene moieties, while the LUMO orbitals have often, but not exclusively, larger densities on the pyridine-2,6-dicarboxamide residues (Fig. 4b and Supplementary Figs 3–6).
The first catalyst contains almost exclusively FeNxCy moieties while the second contains additional crystalline phases, i.e. metallic iron and iron carbide.
In the multiblock copolymers, the tertiary amino groups of the poly amino urethane) segments act as pH-responsive moieties, while the PCL PEG PCL blocks act as biodegradable and temperature-sensitive segments.
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