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A pro-drug (labeled 1) where naloxone and the indolequinone moiety were linked through a carbonate bond was rapidly hydrolyzed in phosphate buffered saline.
The two substituents, a polyhydroxylated ribose mimic and a lipophilic moiety, were linked either in position 2 or 6 of the purine ring in order to explore any possible binding mode.
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The RA-containing lipid molecules from spot No. 3 were identified as 1-OH TAG, in which an RA moiety was linked with the glyceride backbone of TAG (Fig. 3c, Supplementary Fig. S10).
An intramolecular charge transfer (ICT) fluorescent probe, in which the thiourea derivative moiety is linked to the fluorescent 4- dimethylamino) benzamide, has been designed and synthesized.
In a continuing study of hybrid compounds containing the α-bromoacryloyl moiety as potential anticancer drugs, we synthesized a novel series of hybrids 4a h, in which this moiety was linked to a 1,5-diaryl-1,4-pentadien-3-one system.
We report on the synthesis of some novel liquid crystalline polyacetylenes derived from monosubstituted acetylenic monomers where the acetylenic moiety is linked through a short spacer (one or three methylene units and an ether bridge) to a biphenyl mesogenic core.
A series of N-aryl heteroarylisopropanolamines in which an indole or a 3-arylpyrrole moiety was linked to an aryl group through an isopropanolamine linker, were designed and synthesized as potential anti-HIV-1-PR agents.
This moiety was linked to C-2 as indicated by HMBC correlations from the anomeric proton (δ H 4.44) to C-2 (δ C 72.6).
O(11) – H(11) group of cation moiety is linked through hydrogen bonding to O 8) of the carbonyl group of anion and O(10) – H(10) of cation moiety is also linked through hydrogen bonding to O 9) of the carbonyl group of anion.
The piperidinyl moiety was linked to C-16 through C-16 C-17 C-16 C-17 C-16 C-17ations from H-16 to C-17 and C-22 and 1H-1H COSY correlation of H-16/H-17 (Fig. 1).
Steven et al. [26, 27] define a CGC as "a complex in which a π-bonded moiety is linked to one of the other ligands on the same metal centre in such a way that the angle measured between the centroid of the π-system and the additional ligand is smaller than the comparable unbridged complex".
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