Sentence examples for moiety was not from inspiring English sources
Expected agonistic profile towards M1 mAChRs delivered by BQCA moiety was not confirmed.
In contrast, elastase inhibitor III (EI), which also contains the chloromethyl ketone moiety, was not active.
The results suggested that hydroxy substitution at C-4 had a significant impact on the activity and replacement of the tetrahydrofuran group by methyl moiety was not beneficial for the activity.
The structure activity relationship (SAR) analysis revealed that (i) the order of anticancer potency for the 3-haloacylamino chain was following –CH2Br > –CHBrCH3; (ii) the N′-substituent moiety was not essential for the anticancer activity, and a proper alkyl substitution might enhance the anticancer activity.
The 450-nm band observed for pure polymer [23] and probably originates from the π conjugation in the naphthalene-diepoxymethacrylate moiety was not detected for 2,7-NAF.DM chemisorbed on the silica surface (Fig. 6).
The trans -to-cis isomerization of azobenzene is induced by UV light irradiation and leads to a large increase in the dipole moment of these molecules demolishing the chain packing in the azobenzene monolayer and a lower contact angle (the fluorinated moiety was not anymore exhibited).
The results of the above analyses taken together suggest that the α,β-unsaturated moiety plays an indispensable role in the Ca2+ influx and permeability enhancement by compounds 2–5 and NEM, but the moiety is not sufficient.
Low MW compounds, when lacking of a strong basic moiety, are potent cytotoxics, while analogues bearing a strong basic moiety are not.
Therefore, the presence of the amidino moiety, and in general of a basic moiety, is not an absolute requirement for biological activity of α-bromoacrylic derivatives of distamycin.
However, the introduction of a hydroxyl group into the side chain of compound 5 resulting in compound 9 failed to open TJs (Fig. 2C), indicating that the α,β-unsaturated moiety is not sufficient to open TJs.
The binding mode of the acetoacetyl-CoA substrate was found to be that the adenosine diphosphate moiety is not highly stabilized compared with the remainder of the molecule.
