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Alendronate, a targeting moiety that has a strong affinity for bone, was conjugated to PLGA polymer via carbodiimide chemistry.
To our knowledge, exendin-4 analogue 18F-2, a forty amino acid peptide, is currently the largest peptide containing an organosilicon moiety that has been labeled with 18F in one step by nucleophilic substitution.
A novel turn-on fluorescent probe, which coumarin-fused coumarin was used as fluorophore to link with 2, 4- dinitrodiphenyl ether moiety that has high selectivity and sensitivity for H2S and thiols, was designed and synthesized.
In the present paper we describe the first synthesis and evaluation of a novel Mn (II) complex (DTPA-PPDA Mn (II)) which contains a C-15 fatty acid moiety that has high affinity to the heart muscle.
The localization of EerI to the ER membrane by the aromatic domain appears to be responsible for the improved target specificity because replacing this domain with another benzene-containing moiety that has a moderate affinity for the ER membrane produces a compound that has activities closely resembling EerI.
STZ, another weak inhibitor of hOGA, carries a reactive N-methylnitrosourea moiety that has been shown to be toxic to eukaryotic cells by DNA alkylation [29 31] and nitric oxide release [32].
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MALDI mass spectrometry was used to determine the number of DFO moieties that had been added to each molecule of cetuximab.
Other strategies focus on the use of moieties that have an indirect effect, acting, for example, as sequesters of bioactive ligands present in the extracellular milieu that, in turn, will interact with cells.
CO can be used for the detection of oxidases because it binds specifically to heme moieties that have oxygen binding capacity.
Although there are five chemical moieties that have been demonstrated to undergo metabolism in hypoxia, the most common approach employs nitroaromatic derivatives, such as the 4-nitrobenzyl, 4-nitrofuryl, and 2-nitroimidazole groups.
Conventional naturally occurring TAGs found in plant oils and animal fat typically consist of linear fatty acyl moieties that have 16, 18, or 20 carbons (Nelson et al., 2008).
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