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Lipidic prodrugs, also called drug lipid conjugates, have the drug covalently bound to a lipid moiety, such as a fatty acid, a diglyceride or a phosphoglyceride.
Introduction of groove binder moiety such as polyamide enhanced the regional stability of radical molecules and reduced cytotoxicity of the drugs.
Polysilsesquioxanes (POSS) are molecules with the empirical formula (RSiO1.5 n where R is a hydrogen atom or hydroxyl or an organic moiety such as an alkyl, alkene, acrylate or epoxide.
Genetic engineering has led to the development of fusion protein toxins, which are targeted effector molecules that combine a targeting ligand such as a growth factor with a cytocidal moiety such as a plant or bacterial toxin.
The modifications in the substrate resulted mainly in alterations of the conversion rate, but the inclusion of a chiral alcohol moiety such as (R -1-phenylethanol R -1-phenylethanolion of CAL-B enantiopR -1-phenylethanol
A series of compounds containing an α,β-unsaturated carbonyl moiety, such as chalcones and coumarins were designed, synthesized and tested in a variety of assays to assess their potential as anti-Alzheimer's disease (AD) agents.
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The reversible covalent post-translational modification (PTM) of histone proteins by chemical moieties such as phosphate, acetyl and methyl groups constitutes one of the primary chromatin signaling mechanisms.
Surprisingly, the cell performance was dependent on the moietys such as EDOT or BTD of side arms.
The common structure of this family is three consecutive hydroxamate moieties, such as Nδ-acetyl-Nδ-hydroxy-l-ornithine (Aho).
The subtypes presented here are mostly based on how glycans are decorated with specific monosaccharide moieties, such as sialic acid and fucose, which are frequent features in glycan-based antigen epitopes.
The galacturonic moiety was efficiently introduced from galactose using a TEMPO/NaOCl/NaClO2-based oxidation protocol optimized for full compatibility with sensitive moieties, such as allyl ethers and acetates.
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