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Folk differs from FolP1 by transferring phosphorus-c moiety rather than alkyl or aryl group.
Similarly, the other WT1B peptide derivative harboring a benzophenone moiety rather than an aryl azide (WT1B-Fbz), also demonstrated covalent binding to HLA following UV-induced cross linking (Fig. 2C).
However, recent findings indicate that the ETP moiety rather than the structure of Chaetocin is critical for its nonspecific histone lysine methyltransferase inhibitory activity.
On the contrary, purified LTA, at least in the experiments we performed, was unable to bind sub-fraction #5 and this may caused by the lipid moiety rather than the polysaccharide chain.
This energy distribution explains why light in excess is affecting the antenna moiety rather than the reaction center: the probability of generating Chl triplets by intersystem crossing is clearly higher here than anywhere else in the complex.
The presence of the disaccharide in MS/MS furthermore suggested that the nystatin P1 aglycone is substituted at one position with a mycosamine-hexose moiety rather than the two sugar molecules being attached at separate positions.
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Attention was paid to the design of a pro-moiety rather than a parent drug.
The majority of the compounds showed π-π stacking between the pyrimidine-pyrimidine, pyridine-pyridine and acid-acid moieties rather than acid-pyridine or acid-pyrimidine moieties.
An indirect chemical probe method using active species scavengers elucidated that the photo-oxidation mechanism was proceeded via holes and O2− moieties rather than singlet oxygen moieties.
First, because 1 is uncharged its crystal packing is dominated by stacking interactions between aromatic moieties rather than hydrogen bonding or interpenetration.
It is also interesting to note that in all the compounds π-π stacking occurs between the pyrimidine-pyrimidine or pyridine-pyridine or acid-acid moieties rather than acid-pyrimidine/pyridine.
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