Sentence examples for moiety of compound from inspiring English sources

Thirteen new sphingosine-1-phosphate receptor 1 (S1PR1) ligands were designed and synthesized by replacing azetidine-3-carboxylic acid moiety of compound 4 with new polar groups.

Modification of the N-carbethoxy piperidine moiety of compound 2, an M4 muscarinic acetylcholine receptor (mAChR -preferring agonist, led to comAChR -preferringtive M4 magonistonist.

Hence, further optimization study of the biphenyl moiety of compound 3k, focused on improving the pharmacokinetic (PK) profile and hERG inhibition, was conducted.

The docking results showed that the catechol diether moiety of compound 8 played a key role to form integral hydrogen bonds with PDE4B protein while the rest part of the molecule extended into the catalytic domain to block the access of cAMP and formed the foundation for inhibition of PDE4.

The primary structure activity relationship study and docking results showed that the tetrahydroquinoline moiety of compound 4m played a key role to form hydrogen bonds and π-π stacking interaction with PDE4B protein while the rest part of the molecule extended into the catalytic domain to block the access of cAMP and formed the foundation for inhibition of PDE4B.

The primary structure activity relationship study and docking results showed that the 1,2,4-triazole moiety of compound IIk played a key role to form integral hydrogen bonds and π π stacking interaction with PDE4B protein while the rest part of the molecule extended into the catalytic domain to block the access of cAMP and formed the foundation for inhibition of PDE4.

α,β-unsaturated moiety of compounds 9 and NEM is enclosed.

Thorough docking calculations of the seven most potent AChE inhibitors from the set, showed that the hydrogen bond can be formed between amide –NH– moiety of compounds and –OH group of Tyr 124.

Molecular docking studies suggested that the hydrazinyl carbothioamide moiety of compounds (6 10) can in general be accommodated the binding pocket of the breast cancer protein (1JNX) and are responsible for the activity of the whole of the molecule.

Nonetheless, HIBGC9 contains a type III polyketide synthase, which would be expected for the production of the naphthoquinone moiety of compounds in the marinone series (Fig.  5).

Interestingly, substituting the carboxylic acid moiety of compounds showing a strong reduction in phosphoinositide production (PIA, DIA, VPA) with a carboxamide group (yielding the corresponding amides PID, DID, VPD) reduces the inhibitory effect, indicating that amide derivatives are poorly effective for this effect.