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In contrast to luminal and extracellular complex glycosylation, O-linked N-acetylglucos-amine (O-GlcNAc) is a single N-acetylglucsosamine moiety linked to serines and threonines of cytosolic and nuclear proteins (Hart, 1997).
During the last decade, significant progress has been made on the field of biosynthesis and structural elucidation of fungal glycosphingolipids (GSLs), molecules composed of a hydrophobic ceramide moiety linked to one or more sugars.
We report on novel chiral tridentate [NO2]H2 and tetradentate [N2O2]H2 Schiff base ligands containing a planar chiral ferrocene moiety linked to hydroxyl-imine or diimine donors with central or axial chirality.
A novel rhodamine B-based sensor 1 consisting of a rhodamine B moiety linked to the amine end of a 1,4,7,10-tetraoxa-13-azacyclopentadecane was designed and synthesized.
The results show that the O-alkynyloxime moiety linked to azacycles of appropriate size and rigidity (for example quinuclidine and tropane) is a potentially useful muscarinic pharmacophore that can be exploited for the design of muscarinic agonists.
Compound 2e, characterized by a central benzamide moiety linked to an isoquinoline at one side and acetophenone at the other, was the most potent candidate with Ki of 6.47 nM against human AChE.
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The compounds bear three non-reducing, β-linked Gal or GalNAc moieties linked to flexible spacers for an optimal spatial interaction with the binding site of the ASGP-R.
The FTIR spectra of modified polymers suggest the formation of sulphone and/or sulphonamide moieties linked to the polymer backbone.
Air-stable P,N-bidentate ligands L1 L7 with cyclic secondary amine moieties linked to the benzene rings of triphenylphosphine were designed and prepared.
The method enables the generation of structurally diverse molecular hybrids including peptide, lipid, steroidal and sugar moieties linked to the 1,3,5-thiadiazine scaffold.
A series of light responsive linear dendritic BCs consisting of a liquid crystalline aliphatic polyester dendron functionalized with sixteen 4-cyanoazobenzene moieties linked to a linear block of poly methyl methacrylate), poly ethyl methacrylate) or poly styrene) have been investigated.
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