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The small changes in the substituents of the coumarin moiety led to this interesting selectivity profile.
Removal of the acetic acid moiety led to inactive or weakly active target compounds.
Subsequent cleavage of the lipophilic moiety led to reconfiguration of the ligand bound binding cleft.
Controlled oxidation of the endocyclic sulfur atom of the 5-thioxylose moiety led to the corresponding sulfoxides and sulfones.
A distance of four atoms (five bond lengths) between the basic amino group and the terminal aryl moiety led to highest NR2B affinity.
Optimization of the heterocyclic moiety led to the identification of the thiadiazole series of pyrazolones (D) as potent VEGFR-2/KDR kinase inhibitors.
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In plants, photoisomerization of a cinnamate moiety leads to altered gene expression.
Modification of the P1 moiety leads to an increased selectivity versus trypsin.
Specifically, the introduction of a coordinating donor in the ortho-position of the phenyliodine (III) moiety leads to a significant improvement of solubility of a hypervalent iodine reagent.
The investigations carried out on bare ZnO nanofluids as well as PVP-stabilized nanofluids show that addition of a stabilizer, which inhibits diffusion-assisted local aggregation due to attached moiety, leads to reduction in the enhancement of thermal parameters that are observed in bare ZnO nanofluids.
Phosphorylation of Y177 within the Bcr moiety leads to recruitment of the Grb2/Gab2 complex and downstream signalling via SHP2 and PI3K, which is crucial for enhanced proliferation and survival.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com