Sentence examples for moiety it was from inspiring English sources

Furthermore, although hu5c8 was shown to activate human platelets in vitro when it possessed an active Fc moiety, it was without activity in its aglycosyl form in these assay systems.

For the incorporation of fumaryl group into flavensomycinyl moiety, it was assumed that fumaric acid is firstly converted to fumaryl-CoA by BafCI (acyl CoA ligase), and then connected to bafilomycin polyketde backbone by BafCII (malonyl transferase).

Because DOX is a small molecule without a targeting moiety, it was more widely distributed in organs than was free DOX from the conjugates.

In order to achieve diversity with respect to the protecting group pattern of the guanidine moiety, it was envisaged to introduce this functionality at a late stage.

In the earlier structural findings for the compound AMW610 where the Arg residue resided on the heterocyclic moiety, it was observed that insertion of the heterocyclic ring made the peptide backbone more flexible and resulted in several conformational families with very low populations.

By virtue of its Michael acceptor moiety, it is an irreversible inhibitor, which acts by covalent binding to a cysteine residue in the ATP binding domain of EGFR (Cys 797), HER2 (Cys 805), and ERBB4 (Cys 803) [19,20].

Taking AZT as nucleosidyl moiety, it is shown that most of the compounds inhibit HIV replication in TK− cell line, which proves 5′-AZTMP delivery.

Since both of these compounds lack a 1-carboxy moiety, it is reasonable to assume that the 1-carboxy substituent present in the two substrates accepted may be required for binding at the catalytic center.

The TryR active site contains both hydrophobic and acidic regions (for interaction with the spermidine moiety); it is likely that what we are observing is hydrophobic interactions between the hydrophobic regions of our inhibitors and the active site and electrostatic interactions between the positive charge on the inhibitors and the negatively charged region of the active site.

Using different synthesis strategies and functionalization moieties, it is possible to design nanocarriers with specific targeting and drug delivery abilities for many different pathological conditions.

With the versatility of polymer chemistry and conjugation of functional moieties, it is expected these hydrogels can be useful for biomedical applications such as polymer therapeutics and tissue engineering.