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The corresponding feature of the ES symbol, sssN, in the tertiary amine (sssN) moiety, is shown in Figure 1(b).
The palmitoleyl moiety is shown as slate spheres.
A visual representation of this moiety is shown in Supplemental Figure 4.
The structure of the azobenzene moiety is shown in Fig. 1(A).
The C-EDTA moiety is shown as sticks, with carbon atoms colored cyan.
As adenine differs from purine only in containing an exocyclic N6 amine, this moiety is shown to be essential for the binding of these two aptamers to CoA.
Similar(53)
The corresponding modes for an imidazole moiety are shown in Figure 2 (C).
The ETO moiety was shown to interact with the nuclear receptor co-repressor (N-CoR) complex, which includes mSin3A and the histone deacetylase, HDAC1.
In particular, analog 21l, which possesses a cyclopentyl oxime moiety, was shown to have excellent pharmacological effects on retinal vascular leakage in a diabetic mouse model.
However the presence of N-linked sugar moiety was shown to be unimportant for tumor suppressive activity but was critically important for its immunoregulative activity which demonstrates that different molecular mechanisms are involved in these two types of biological functional activities attributed to AFP.
2D structures of these compounds along with the common moiety are shown in Figure 3(b).
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