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The resorcinol moiety is required for optimum CB2 inverse agonist activity and selectivity.
PML/RARA, but not PML/RARAL73E, efficiently developed APL (Fig. 6a), in line with our observation that sumoylation of PML moiety is required for efficient leukemogenesis in vivo30.
Whereas one large benzyl moiety is required for high σ1 receptor binding, a second large N-substituent is not tolerated by the σ1 receptor protein.
Our data show that the diaryl borinate moiety is required for biological activity and that the substitution pattern of the aryl rings can influence TRPV6 versus SOCE inhibition.
A combination of specific hydrogen bonding and lipophilic elements on the A-ring moiety is required to achieve potent GR agonist activity.
Only the first compound was significantly inhibitory, suggesting that the presence of the azoxy moiety is required for growth inhibition.
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In addition, moderate-sized lipophilic substituents at the para-position of the 3-aryl moiety were required for dual COX-2/5-LOX inhibitory activity.
XRD studies thus confirm that optimum concentrations (3 8 mM) of organic moiety are required to obtain the desired IO perovskite.
Extensive structure/function analyses that we performed (to be published separately) have confirmed that integration of all these moieties is required to enable performance of these compounds as detectors of apoptosis.
Our data indicate that fusion of the GAP and PTPase moieties is required for SptP-dependent VCP dephosphorylation, compatible with evidence from many mammalian tyrosine phosphatases that employ noncatalytic domains to mediate substrate interactions (Tiganis and Bennett, 2007), and is presumably responsible for the observed specificity of SptP.
It is noteworthy that the short PolyP forms are labeled by Toluidine Blue but remain unlabeled by DAPI, indicating that at least four polyphosphate moieties are required for negative staining by DAPI.
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