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SAR studies showed that the undecane core with at least one furan moiety is preferred for IN inhibition.
An amide moiety is preferred over a nitrile in potent 5-HT4R ligands.
Similar(58)
As alcohol moiety ethanol is preferred due to its low toxicity for the production organism, compared to methanol or butanol and the ease of its microbial production.
SARs studies revealed that the N-heteroarene moiety attached to the thiourea is preferred over the phenyl ring for the R2 substituents, while the hydrophobic aromatic group is beneficial for improving the activity.
For the 5-HT3AB receptor, an alcohol moiety at position R (as observed for compound 1) is preferred, but a hydrogen atom at R also results in high affinity (compound 24).
As noted in previous work with the DHFR enzyme from S. aureus or B. anthracis, a modification of three to four carbon lengths at this chiral center is preferred, as is an aromatic or more planar moiety such as OSU34 (phenyl) and OSU53 (isobutenyl).
This method is preferred by many researchers because complexation depends upon configuration of the FAs moieties due to the presence of multiple double bonds, rather than pure physical properties such as melting point or solubility [5, 6].
The latter is preferred.
More is preferred to less".
Amitriptyline is preferred.
Sometimes, complete anonimity is preferred.
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