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As the chemical shifts are very close to each other, the asymmetry of H-bond in enolone moiety is not strongly expressed.
In some instances, even with mapping of hydrogen atoms, one or more conserved moiety is not computed with the aforementioned approach [26].
Therefore, the presence of the amidino moiety, and in general of a basic moiety, is not an absolute requirement for biological activity of α-bromoacrylic derivatives of distamycin.
However, spin interaction between carbene and nitronylnitroxide through 3,3′-diphenylacetylene moiety is not strong enough to form high-spin chain having long correlation length for 4.
Unlike known affinity labels, the affinity moiety is not retained in the protein product, but is extruded upon acylation of the protein.
The binding mode of the acetoacetyl-CoA substrate was found to be that the adenosine diphosphate moiety is not highly stabilized compared with the remainder of the molecule.
Similar(21)
Expected agonistic profile towards M1 mAChRs delivered by BQCA moiety was not confirmed.
In contrast, elastase inhibitor III (EI), which also contains the chloromethyl ketone moiety, was not active.
It has been observed that the two rings in the anion moiety are not coplanar and twisted by 45.77 (6)°.
Low MW compounds, when lacking of a strong basic moiety, are potent cytotoxics, while analogues bearing a strong basic moiety are not.
In vitro evaluation highlighted that modifications on the phthalimide moiety were not tolerated and that lipophilic substituents on the central phenyl ring were functionally essential.
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