A convenient approach to the construction of kanamycin derivatives, in which the C4′-position on ring I of neamine moiety was modified, was developed.
A biphenol-type epoxy resin, which has a mesogenic group in the backbone moiety, was modified with a reactive elastomer (CTBN).
Three different structural moieties were modified in the search for optimal glioblastoma activity: the 1,3-diazinane moiety, the aryl moiety, and the heteroatom linker.
Diversified rates of parent drug release were observed when the chemical structure of both the solubilizing and the spacer moieties were modified.
KL020 and KL021, whose sulfonyl moieties were modified with phenyl or cyclopropyl groups, showed reduced period effects.
They are antisense RNA oligonucleotides in which the ribose moiety of an LNA nucleotide is modified to increase stability and specificity.
In details, the ribose moiety of an LNA nucleotide is modified with an extra bridge connecting the 2′-oxygen and 4′-carbon, which 'locks' the ribose in the 3′- endo conformation.
This would indicate STIM1 is modified by a single ubiquitin moiety.
Here, we combined Laponite with an injectable PEG-based adhesive that is modified with biomimetic catechol adhesive moiety (PEG-D4, Scheme 1).
Furthermore, the N7 atom is modified with a (2,3-dihydroxypropyl) moiety that possesses a stereo centre at the carbon of the secondary alcohol (Fig. 1B).
