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Finally, no similar bioisostere was found among the results obtained with SwissBioisostere for BoBER's bioisostere of fragment 3 in which an acidic moiety is bound to a furan ring.
In the resultant ThyX-NADP+ binary complex, the AMP moiety is bound in a deep pocket similar to that of the same moiety of FAD in the ternary complex, while the nicotinamide part of NADP+ is engaged in a limited number of contacts with ThyX.
204LPMFHVAAL212 residues show homology to the 9-residue gate motif (G-motif), which in homologous proteins interact with the residues of the C- terminal domain after the AMP moiety is bound to the protein and thus keeps the enzyme in the closed conformation required for catalysis [23].
NO-ASA consists of traditional ASA to which an NO-releasing moiety is bound via a spacer.
The phosphate moiety is bound in a positively charged pocket formed by pol λ residues Arg275, Arg308, and Lys312.
On the other hand, the methylpiperidine moiety is bound to the nitrogen of the indole, and the ion at m/ z 98 is observed as the base peak (Fig. 3d).
Similar(51)
Using terminal protection of small molecule-linked DNA chimeras, which can protect DNA from degradation by various exonucleases when the small molecule moieties are bound to their protein target, we designed a loop probe, where the 3′-end was modified with biotin to resist digestion by exonucleases in the presence of target SA.
Motion of this sort has been suggested as a possible means by which lipid moieties are bound for transport [12], and it is thus assumed that such motion is not an indication of loss of structure, but rather a native dynamics of this protein.
They sense NO by means of a heme moiety that is bound to their N-terminal extensions.
These alleles are defined by their ability to bind glucose or rhamnose at either position 2″ or 6″ to the glucose moiety that is bound to the 3-position of flavonols.
It has been shown to phosphorylate and inactivate BAD (Datta et al, 1999), by converting it to an inactive moiety that is bound to the cytosol, and is therefore unable to hetero-dimerise with BCL-2 and BCL-XL (Yang et al, 1995).
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