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The aldehyde moiety forms a covalent bond with the catalytic Ser135 of NS3.
In the first step, potentiodynamic electropolymerization of the thienyl moiety forms a cationic polyalkylthiophene that is soluble in select organic solvents.
This second interaction is notable because the ATP adenine moiety forms a similar π π stacking interaction with F475, per the 3WGU structure [47].
The central 1H-pyrazolo[3,4-d]pyrimidine moiety forms a cation-π interaction with R544, and one if the chlorobenzene moieties forms a π π stacking interaction with F475.
Its phosphate moiety forms a hydrogen bond with the N267 backbone nitrogen, thereby presumably stabilizing this helix.
The 2′-OH group of the ribose moiety forms a hydrogen bond to Thr-135, and the 2′-OH (2.4 Å) and 3′-OH (2.5 Å) groups are coordinated to the third metal (Mγ).
Similar(50)
In one molecule, the phosphate moiety forms an intramolecular hydrogen bond with R48 in helix αC, which may contribute to positioning and stabilization of this catalytically important helix.
38, 39 In addition, the cyanidin hydroxyl functional group at position 4 of the B ring (3,4-dihydroxyphenyl moiety) forms an H-bond with the backbone acceptor oxygen atom of Pro434, thereby contributing to an increase in binding affinity.
(3) The NS5 MTase transfers a methyl group to the N7 position of the guanine moiety forming a cap 0 structure (7meGpppA-RNA) [7], [21].
Inhibition of AChE by OPs is obtained by the P = O moiety forming a covalent bond with the active site of the enzyme.
These species were proposed to evolve by retro-donating electron density from the metal and pushing the sulphide moiety forming a α-carbonyl gold(i) carbene 47 that underwent an intramolecular Friedel Crafts reaction to give 48 and then 49.
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