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Introduction of methyls to the ribose moiety does not lead to inhibition of TBEV reproduction.
The chemical nature of a meta-substituent on the 5-APT pendant phenyl moiety does not significantly affect H1 affinity.
Moreover the absence of the 1,2-dithiolane moiety does not completely abolish antioxidant effects thus demonstrating that these compounds are distinct new chemical entities and not merely lipoic acid prodrugs.
The TT moiety does not have significant influence on the energy level when incorporated with BDT and BT units in alternative copolymers, but can significantly affect the phase separation behavior when mixed with PC61BM by improving the crystal structural order.
Our results indicate that, regardless of the genomic context, the histidine moiety does not become incorporated in proteins via ribosomal translation, and that disruption of the TLS in either viral RNA does not perturb the viral translation patterns.
The crystal structure of the product revealed that the bipy moiety does not coordinate to the Sn atom, but forms a cyclic tetrameric adduct of formula [Ph3SnL1H(H2O)]2 · bipy2 through hydrogen bonding between the water ligand of Ph3SnL1H(H2O) and the bipy N atoms.
Similar(32)
Whereas modifying the aminoethyl moiety did not significantly change TRPV6 inhibition, substitution of the phenyl rings of 2-APB did.
In previous structure activity relationship studies, we have demonstrated that certain modifications around the fucoside moiety did not cause significant cytotoxicity loss.
However, the 3R*-methyl compound 7, bearing a 5-iminoethyl moiety, did not inhibit any of the NOS isozymes, although l-N-iminoethylornithine (l-NIO) potently inhibited all three.
Biological tests revealed that repeating unit 3, lacking the lipid moiety, did not stimulate a pro-inflammatory response in human monocytes (hMNCs).
Chlorination and bromination on α-position of 1,3-diketone moiety do not change the preferential form being cis keto-enol as in parent compounds.
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