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Exact(7)
Structure-property analysis indicates that the highly conjugated 5-nitroheteroaryl moiety connected to the phthalazin scaffold play an important role in the antichagasic activity of these phthalazines.
We report the design, synthesis, QSPR and QSAR of a new class of H3-antagonists, having a 2-aminobenzimidazole moiety connected to the 4 5) position of an imidazole ring through di- or tri-methylene chains.
The design of profen hybrids containing a NO donor moiety connected to an aliphatic spacer led to compounds with a similar cyclooxygenase inhibition compared to their parent profen and with significant antiproliferative activities on PC3 cells.
Compounds 25 31 having a secondary amine moiety connected to the phenyl ring via eight CH2 units spacer were found to be the most potent inhibitors with IC50 value lower than 220 nM and 48 nM against AChE and BChE, respectively.
LPS is composed of a lipid A moiety connected to chains of polysaccharide.
The AuCl moiety connected to the phosphaalkene of 8 contributes to the HOMO with a d xy orbital localized on the Au and a p orbital localized on the chlorine atom.
Similar(53)
For 1-O (E) -caffeoyl-6-O (S) -brevifolincandoxyl-β-D-glucopyranose (31) and 1, 3-di-O-galloyl-6-O (S) -brevifolincarboxyl-β-D-glucopyranose (32), their C(6) of glucosyl moiety connect to a brevifolincarboxylate group.
In each 3a and 3b, the phenothiazine moiety is connected to a nitrile group through a conjugated double bond, and these molecules are anticipated to show non-linear optical (NLO) properties.
The HMBC correlation of H-1′ (δ H 4.45, d, J = 7.5 Hz) to C-3 (δ C 86.3), indicated that the tetrasaccharide moiety was connected to the aglycone at C-3.
The sugar moiety was connected to C-3 atom as shown from its HMBC spectrum cross peaks H-1′/C-3.
The Martin group recently developed a partial bisubstrate inhibitor where the SAM adenosine moiety is connected to the guanidinium group (35).
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