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Generally, their shape is elongated, with a hydrophilic end or head attached to a hydrophobic moiety by a short intervening region of intermediate polarity.
One was the replacement of the alkylsulfonamide moiety by a phenylsulfonamide to avoid the production of agonist metabolites.
Furthermore, replacement of the CN group and the intact amine moiety by a hydroxyl group as well as degradation of the amine substituent were observed.
Each library component (1) consists of a variable peptidyl component linked to a biotinyl moiety by a 4-mercaptobenzoyl linker in thioester format.
However, the replacement of the piperazine moiety by a 1,2,3,6-tetrahydropyridine 1,2,3,6-tetrahydropyridinethyl caringamine 4-arylpiperazine-ethyl 4-arylpiperazine-ethyl 4-arylpiperazine-ethylfinity.
Three generations of dendritic-linear copoly arylene ether)s containing aryl sulfide and aryl sulfone groups, and aryl fluoride terminal functionality, have been synthesized using the divergent approach and an activation/condensation sequence that involves oxidation of 4-fluorophenylthio groups and the displacement of the activated halide moiety by a phenolate ion.
Similar(41)
The O-dialkylaminoethyloximinothienopyrrolizine structure was deduced from molecular modeling studies by replacement of an amidine moiety by an oximino one.
Balaxiflorin A (98) has a galloyl ester group at C 9) and its C 7), C(9') positions combines an epoxy lignan moiety by an oxygen atom [5].
Based on molecular modeling analysis of the catalytic domain of OfHex2, a series of novel naphthalimide-scaffold conjugated with a small aromatic moiety by an alkylamine spacer linker were designed and evaluated as efficiently competitive inhibitors against OfHex2.
Force field parameters for TO were adapted from existing parameters for DOPC, by replacing the phosphocholine moiety by an oleoyl chain.
Conservation relations (molecular balances) allow for the replacement of the ODE of one species for each conserved moiety by an algebraic equation, and can be defined in the section #molecular balances.
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