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Exact(6)
W433 is considered to interact with −1 GlcNAc through a hydrophobic stacking interaction, holding this moiety at this position during the catalytic reaction.
To investigate the possibility of placing a relatively large protein moiety at this site of B19, fluorescent virus-like particles (fVLPs) of B19 were developed.
This erroneous prediction could probably be attributed to the R2 position, whereas, the majority of compounds are substituted by an indole linked to another moiety at this position this compound has just an indole moiety at the R2 position.
Compound 1 is a natural R. sin-1 lipid A having a 27-hydroxyoctacosanoic acid at C-2′, compound 2 contains an octacosanoic acid moiety at this position, and compound 3 is modified by a short chain tetradecanoic acid.
The ability of p9Y to form fibrils rapidly at pH 1.1 indicates that incorporation of a phosphate moiety at this site can be accommodated within the fibrillar architecture.
A phosphate moiety at this position could disrupt the interaction of the tryptophan side chains with the PTHrP-ncNLS, likely reducing the binding affinity for importin β and hence down-regulating nuclear import of PTHrP.
Similar(54)
Together, this supports the notion that ubiquitin moiety at the N-terminus may protect the protein from proteolytic attack in transgenic plants.
This supports the notion that a hydrophobic moiety at the "R" position is important for the protein binding and the wide range of antiviral activity against CVB4 and HSV.
With this scaffold, maximal activity was observed with an aromatic moiety at the 2-position with (R) stereochemistry.
We emphasise that PC-Os identified in this screen are not PAFs as they harbour a fatty acid moiety at the sn-2 position instead of the acetyl moiety (Supplemental Table S2).
To confirm this observation we studied a 5′-flap substrate with a phosphate moiety at the 3′ end of the upstream strand in place of a hydroxyl group.
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