Your English writing platform
Discover LudwigExact(7)
It has been observed that the two rings in the anion moiety are not coplanar and twisted by 45.77 (6)°.
Low MW compounds, when lacking of a strong basic moiety, are potent cytotoxics, while analogues bearing a strong basic moiety are not.
Herein, we demonstrate that some simple molecules containing a vinyl sulfone moiety are not thiol-specific alkylants since they react with some albumin nucleophiles including side chains of Cys34 and His146.
If the third splitting observed in our experiments between pH 7-10 is due to a slowly exchanging proton, then generating the gallate radical in D2O should produce an EPR spectrum showing only two proton splittings as the protons on carbons 2 and 6 of the gallic moiety are not exchangeable.
The 1H-NMR of compound (11) in DMSO-d 6 showed that the two ethyl groups of the diethylamino moiety are not equivalent, as indicated from their chemical shift values, where the two methyl groups are observed at 1.09 and 1.15 ppm as two triplets and the methylene groups are observed at the range 3.50 3.53 ppm as a multiplet.
The interactions of His with the heme thiolate moiety are not constant and change somewhat along the catalytic cycle.
Similar(53)
Expected agonistic profile towards M1 mAChRs delivered by BQCA moiety was not confirmed.
In contrast, elastase inhibitor III (EI), which also contains the chloromethyl ketone moiety, was not active.
As the chemical shifts are very close to each other, the asymmetry of H-bond in enolone moiety is not strongly expressed.
In some instances, even with mapping of hydrogen atoms, one or more conserved moiety is not computed with the aforementioned approach [26].
Therefore, the presence of the amidino moiety, and in general of a basic moiety, is not an absolute requirement for biological activity of α-bromoacrylic derivatives of distamycin.
Write better and faster with AI suggestions while staying true to your unique style.
Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com