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Hopefully, modification and reconstruction of sugar moieties will lead to new aminoglycoside derivatives that will overcome the undesirable properties of the naturally occurring compounds.
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Oxidative attack by hydroxyl radicals on the deoxyribose moiety will lead to the release of free bases from DNA, generating abasic or apurinic sites.
The preliminary biological assays suggest that the replacement of trans olefin moiety with amide bond will lead to an unbeneficial effect on the inhibition against HDACs.
Phil Jagielka will lead England.
Ryan Theriot will lead off.
Incorporating crown ethers into secondary coordination sphere ligand frameworks for transition metal chemistry will lead to new potential methods for controlling bond formation steps, and routes that couple traditional ligand frameworks with these moieties are highly desirable.
Larger contents will lead to larger enhancements.
Gas exports will lead the way.
Quite where this will lead is unclear.
A different conductor will lead each one.
"That will lead to industrial action".
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