METHB contains epoxide and methacrylate moieties, which undergo cationic and free-radical photopolymerization, respectively.
In all cases it is the 1,3-indandionyl moiety which undergoes electroreduction, whilst the pyridinium (dihydropyridine) part is not reduced within the potential range accessible to polarographic study.
The prodrug includes a triazolium salt linked to an aminocarboxyl moiety, which undergoes enzymatic activation followed by spontaneous chemical degradation to release 2. Prodrug 1 showed high chemical stability and water solubility and exhibited strong antifungal activity against systemic candidiasis and aspergillosis as well as pulmonary aspergillosis in rats.
Entry 5 shows the p-hydroxyphenacyl moiety, which undergoes a photo-Favorskii rearrangement to release X–.
The structural information about the critical interactions between DHNA and the trihydroxypropyl moiety of the substrate, which undergoes bond cleavage and formation, has been revealed by our structures of SaDHNA in complex with neopterin (NP) [PDB 2NM2] and with monapterin (MP) [PDB 2NM3], respectively [ 16].
Outer sphere nucleophilic attack of the π-allylrhodium III) moiety[ 17, 18] of 15 by C5 of the barbituric acid then gives spirodialin 3 a and rhodium(I) species 16, which undergoes Cu(OAc)2-promoted oxidation to regenerate 10.
By referencing the DQ-DQ time signal, the information content of the pattern can be divided into the sidebands and the centerband, with the former reflecting only the moieties which have undergone a reorientation, and the latter predominantly containing contributions from moieties which have remained in, or returned to, their initial position.
7 A ω-transaminase (ω-TA) 8– 10 catalysed regio- and stereoselective monoamination of 3 at the sterically less demanding (ω-1 -keto moiety, yielding preferentially amino-ketone 4, which underwent spontaneous ring-closure to give the corresponding Δ1-piperideines 6 in enantiomerically pure form.
The results show that unlike activated nitriles which undergo the known electrohydrodimerization (EHD) process in protic media, forming "tail-to-tail" dimeric products, the dimerization in acetonitrile affords mainly "head-to-tail" dimers and other products involving addition of "H" and "CH2CN" moieties to the carbon carbon double bond.
This is consistent with the close proximity between anthracene moieties, which results in the observed shielded signals as an effect of anisotropy.
