(22) Several hypotheses for the observed conductance switching were tested by modifying the molecular design of the OPE moieties.
Various nested models were tested where the Hill coefficients and AUC50's of the active moieties were assumed equal.
The pyrethroids that were tested reflect a diversity of structures, including six with an α-cyano phenoxybenzyl moiety (β-cyfluthrin, λ-cyhalothrin, cypermethrin, deltamethrin, esfenvalerate and fenpropathrin) and six without this moiety (bifenthrin, S-bioallethrin, permethrin, pyrethrins, resmethrin and tefluthrin).
Due to the relatively low resolution of the data for the ligand complexes and the consequent uncertainty in the exact positions of the side chains, the plausibility of the proposed hydrogen bonds to the hydantoin moiety of the ligand was tested by conducting simulations of the occluded conformation of Mhp1 with the L-BH and L-IMH substrates.
A number of 1,1′-disubstituted ferrocenes, with a chiral carbon atom and a thiourea moiety in the substituents, were prepared, and their enantioselective recognition was tested.
This hypothesis was tested by incorporating the 2,4-dinitrophenyl (2,4-DNP) moiety at the terminus of a decyl chain in the hydrophobic face of the dendron.
The reaction was tested for the most common saturated and unsaturated NHC ligands bearing N-aryl moieties (Table 1, entries 1 4).
With an intention to synergise the antibacterial activity of chalcones and oxazolidinones, several hybrid compounds possessing both chalcone and oxazolidinone moieties were synthesized and tested for antibacterial activity.
A series of hydrazinecarbothioamide derivatives incorporating ethyl, phenyl, tolyl, benzyl, and allyl moieties were prepared and tested as possible inhibitors of three members of the pH regulatory enzyme family, carbonic anhydrase (CA; EC 4.2.1.1).
Based on this scaffold, a series of truncated mimics comprising biphenyl, amine linker and 2-alkoxy-3-phosphorylpropanoate moieties were designed to test their TGase inhibitory activity.
