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The synthesis of novel, symmetrical zinc and manganese phthalocyanines bearing eight ethynylthiophene moieties was achieved by cyclotetramerization of 4,5-bis(thiophen-3-ylethynyl phthalonitrile thiophen-3-ylethynyl phthalonitrile
Subsequent deprotection of the TACN and adenine moieties was achieved with TFA and ethanedithiol (EDT) as scavenger (Scheme 1).
For MPTMS-RSNO coatings, thermal decomposition of the S-nitrosothiol moieties was achieved using a light-shielded sample flask and the addition of DTPA to chelate trace copper.
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Elimination of the O-glycan moiety was achieved with modified linkers containing only glycine residues.
An efficient and attractive regioselective synthesis of a series of novel pyrazoles containing the trifluromethyl moiety was achieved using Cu OTf 2/Et3N as an efficient catalytic system under ultrasonic irradiation.
Deprotection of the amino acid moiety was achieved by hydrolysis and the final radiotracer was purified by semi-preparative HPLC and obtained, after reformulation, as a physiological and injectable solution.
Thus, introduction of the DOTA moiety was achieved through its selective addition to the β or ε side chain amino group of a Dpr or Lys residue, respectively, introduced at position 29 which was found to be tolerant to amino acid replacement [25, 26].
Moreover, like for the protection of exocyclic amines, protection of the sugar moiety was achieved by choosing an acid labile group such as an isopropylidene group that can be easily removed using 90% aqueous trifluoroacetic acid.
Concerning the dissymmetrical 5-azaindolocarbazoles derivatives, with both an indole moiety and a 5-azaindole moiety, the synthesis was achieved using two very efficient key steps.
Display of the targeting moieties on the viral surface was achieved through fusion to the N-terminus of gp64, the major envelope protein of the Autographa californica nuclear polyhedrosis virus (AcNPV).
The coupling of the methyl aryl haloalkyl phosphoramidate moiety to the nucleosidic part was achieved either using either P III) or P V) chemistry.
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