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Owing to unique chemical architecture, in which polymer chains are densely packed and tethered on the surface by one chain end, polymer brushes possess the flexible platforms for any number of desired functional moieties to be loaded on, as well as a variety of potential applications in the areas of nanotechnology, biomaterials, lubricants, and so forth.
Most proteasomal substrates require ligation of ubiquitin moieties to be recognized and degraded by the proteasome [ 12].
Second, the conjugation method should be sufficiently versatile to allow a variety of moieties to be conjugated to a broad range of antibodies.
This prototype analytical system features femtomol sensitivity for both pulsed amperometric detection and mass spectrometric detection [ 25] allowing the relatively low abundant O-sulfated-glycan moieties to be detected.
This system combined a well-validated unnatural amino acid incorporation technique using an engineered Amber codon suppressor pair with intein mediated expressed protein ligation (EPL), which allows functional moieties to be added to the C-terminus of Protein Z.
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Experimental results proved this novel BODIPY compound with the benzimidazole moiety to be a good candidate for pH probe applications.
The first region of the tricyclic moiety to be explored was the C 3) benzyl thiol moiety.
This demonstrates that there is an absolute requirement for the piperidine moiety to be equatorial and conversely for the aromatic moiety to be in an axial conformation in order for BTCP analogues to inhibit TryR.
This indicates that Rad5 does not require the first ubiquitin moiety to be attached to a specific site on PCNA.
The production/synthesis of oligonucleotides with functional moieties has to be a scalable process (chemically).
Hence, unsaturated oleic moiety appears to be critical in nanotube formation.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com