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A new D π A type intramolecular charge transfer (ICT) based fluorescence probe have been designed and synthesized by appending imidazole (donor, D) and benzothiazole (acceptor, A) moieties through a thiophene bridge.
An intramolecular charge transfer (ICT) based fluorescence turn-on ratiometric probe BTIM (D π A type) has been designed and synthesized by bridging imidazole (donor, D) and benzothiazole (acceptor, A) moieties through a thiophene ring.
An efficient and simple photoinduced electron transfer (PET) based fluorescence turn On probe 7 has been designed and synthesized by bridging naphthalimide and thiophene moieties through a piperazine unit.
In our strategy, DNA hairpins H1 and H2 are dual-labeled with pyrene moieties through a six-carbon-atom spacer at each end; and a single-stranded DNA primer is designed to contain two small molecules near each end.
From the above SAR data, we found that the core structure of adamantyl ethanone linked to methyl 2-thiophenyl or methyl 2-furanyl moieties through a sulfoxide or sulfone group normally generates potent inhibitors of 11β-HSD1.
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The building block of inositol moiety was synthesized starting with myo-inositol and assembled with the biotin-linker moiety through a phosphate linkage.
A series of pyrenyl derivatives has been synthesized following a four-step strategy where the pyrene nucleus is attached with a basic heterocyclic moiety through a carbon linker.
Since conserved moieties consist of a set of atoms that follow the same path through a metabolic network, in principle, it is sufficient to isotopically label a single atom within a moiety to detect the possible paths of that entire moiety through a metabolic network [24].
Nucleotide sugars [nucleoside diphosphate sugars NDP-sugars)] are composugars NDP-sugarsde diphosphate (NDP) linked to a sugar moiety through a chemically activated phosphoester bond (6).
Also compound 2 was considered in which R-roscovitine is linked to a nitrooxy substituted moiety through a vulnerable ester group.
To identify cell-surface proteins that contain closely spaced thiols, they attached a biotin moiety through a spacer arm to the primary amino group of the γ-glutamyl residue of GSAO to afford GSAO-B.
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