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An additional aim of derivatisation is the introduction of chemical moieties that improve detection by liquid chromatography ultraviolet or fluorescence [ 5, 12].
Sophisticated organic chemistry can also enable the functionalization of fluorescent dyes with chemical moieties that improve the function of these polycyclic aromatic groups in biological contexts, such as polyethylene glycol or sulfonates.
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Based on this view and inspired by its known anti-amyloid properties, we have functionalized resveratrol with a phosphoryl moiety (4′-O-PR) that improves its solubility and pharmacological properties.
OAVs efficacy can be also improved through the exchange of the capsid fiber of the virus or addition of specific moieties that will retarget vectors to enter the cell through alternative receptors [ 3].
N-Glycans are mobile moieties that often inhibit crystallization.
Although built on a promiscuous scaffold, we anticipated that the larger substituents of our improved inhibitor (the cyclobutyl and benzimidazole moieties) would improve its kinome wide selectivity.
We therefore expect that the use of such activatable units, grafted to targeting moieties, will improve significantly the contrast of images obtained in the future.
Covalent methods involve chemical modification (or chemical functionalization) of the CNT walls with various chemical moieties to improve solubility in solvents [25].
Nevertheless, there is a need for new molecular imaging moieties to improve the clinical staging and monitoring of PCa in order to identify the optimal course of treatment for the disease.
Thus, in the process of designing polymersomes, a variety of amphiphilic block copolymers with different molecular weights are used to develop intelligent or sustained released formulations and to modify the stability of the system and bilayer thickness or to functionalize the particle with targeting moieties to improve the delivery efficiency.
This compound was developed based on an optimization strategy introducing sugar moieties to improve the pharmacokinetics [ 28, 47].
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