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These alcohols possess hydrophobic and charged structural moieties that contribute to electrostatic and hydrophobic interactions with adsorbed surfactants, in analogy to the mechanism of siderophore adsorption discussed above.
Based on the structure of dabrafenib, therefore, careful structure-activity relationship studies help to differentiate the moieties that contribute to its RIP3 inhibition from the ones that contribute to its Raf inhibition.
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In the oncogenic fusion Bcr-Abl, the Bcr moiety contains important regulatory elements that contribute to constitutive activation and cellular transformation.
The roles of three dystroglycanopathy-causing proteins that contribute to synthesis of the LG-binding moiety (FKRP, FKTN and TMEM5) are largely unknown.
Per residue energy profiling that contribute to free energy of binding shows that there is an unfavourable energy at the site where Asp157 interacts with 2-thiazolidinone moiety of LAT.
The good overall properties of isohexide-derived polyimides can be contributed to the incorporation of unique isohexide moieties that were rigid, thermally stable, fully aliphatic and chiral.
Protein molecules are amphiphilic moieties that spontaneously adsorb at the air/solution (A/S) interface to lower the surface energy.
N-Glycans are mobile moieties that often inhibit crystallization.
The experiments combining with computations indicate that the electron transfer from inorganic moieties to organic moieties contributes to the luminescent behavior of the Zr-NDC MOF besides the NDC ligand.
These are: Phenylalanine, which provides the phenolic moiety, a branched amino acid, either valine or leucine, that contributes with the lateral aliphatic chain, and γ-aminobutyric acid (GABA), the amino donor required to form vanillylamine from vanillin ([ 12]; Figure 1).
The predicted substituent dependence of GlcNAc puckering, and that of uronic acids (Sattelle et al. 2010), leads us to hypothesize that the slower exchange kinetics of sulfonated GlcNAc residues (favoring a more rigid C1 chair) may, in concert with electrostatic repulsion of sulfo moieties, contribute to the observation that HS S-domains are more rigid than NA-domains (Mobli et al. 2008).
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