The reversible covalent post-translational modification (PTM) of histone proteins by chemical moieties such as phosphate, acetyl and methyl groups constitutes one of the primary chromatin signaling mechanisms.
The common structure of this family is three consecutive hydroxamate moieties, such as Nδ-acetyl-Nδ-hydroxy-l-ornithine (Aho).
The subtypes presented here are mostly based on how glycans are decorated with specific monosaccharide moieties, such as sialic acid and fucose, which are frequent features in glycan-based antigen epitopes.
Taken together, tertiary amine-derived moieties such as CPDM and PBA represent an efficient yet safe strategy to achieve lung-targeted drug delivery.
Engineering can entail alteration of amino acid sequence, alteration of the glycocomponent of a glycosylated protein, or the covalent attachment of chemical moieties such as polyethylene glycol.
Recently, biomaterials have been designed to contain redox-sensitive moieties, such as thiols and disulfides, to impart responsive degradation and/or controlled release.
Star-shaped macromolecules decorated with fluorescence moieties such as pyrene and anthracene have been developed, which exhibit aggregation enhanced excimer emission (AEEE).
The structural design of prodrugs using delivery moieties such as D-phenylglycine for improving intestinal absorption of levodopa is presented as an example.
Also, MSCs may carry bioactive moieties, such as growth factors and cytokines with the goal of replacing, repairing, or improving tissue and organ functions in the human body.
This paper presents synthesis and characterization of new rigid core dye composed of two chromophore moieties such as azobenzene and stilbene parts.
In cancerous cells, aberrant short-terminated glycan moieties such as TF-antigen and sialic acid are expressed on cell surfaces, becoming cancer antigens.
