Sentence examples for moieties required for from inspiring English sources

The highly rigid [4.3.3]propellane scaffold was used to fix the three dimensional orientation of the pharmacophoric moieties required for σ affinity.

The relatively simple structure of ellipticine has prompted chemists to design various structural modifications in order to obtain either more active derivatives or information on the structural moieties required for pharmacological activities.

However, considering that the pharmacological target of statins, the 3-hydroxy-3-methyl-3-glutaryl coenzyme A (HMG-CoA) reductase, is one of the upstream enzyme of the mevalonate pathway, its inhibition may determine a substantial impoverishment of additional lipid moieties required for a proper cellular function.

Unlike related carbon nanomaterials, hRGO retains the necessary electronic properties while providing the high percentage of available oxygen moieties required for effective covalent functionalization.

Together, these data suggest that the chemical moieties required for the antifungal properties of these compounds are also important for their alleviation of IFITM3's antiviral actions.

Glucose metabolised by the pentose phosphate pathway (PPP) generates ribose moieties required for nucleic acid synthesis and the NADPH required for the biosynthesis of lipids and nucleotides [ 10, 16, 17].

These molecules incorporated a 1-methyl-2-nitro-1H-imidazole hypoxia-activated trigger (present in the clinically evaluated compound TH-302) in a manner that masked a reactive imine moiety required for cytotoxic activity.

Here, we have characterized piperazine and piperidine triazole ureas that combine the high potency attributable to the triazole leaving group together with the bulky aromatic benzodioxolyl moiety required for selectivity, culminating in compound JJKK-048 that potently (IC50 < 0.4 nM) inhibited human and rodent MAGL.

Moreover, Sven0925 possesses a conserved serine at position 50 that is predicted to be the catalytic residue needed for the addition of the 4′-phosphopantetheine moiety required for the activity of the holo-ACP (see Fig. S2 in the supplemental material).

The first approach towards alkene 6 started with acetonide protection of d-ribose (9) as outlined in Scheme 2. Initially, we intended to install the alkene moiety required for the cross-metathesis reaction by Tebbe olefination of the corresponding methyl ketone, which should be accessible from terminal alkene 14 after Wacker oxidation.

It is noteworthy that the short PolyP forms are labeled by Toluidine Blue but remain unlabeled by DAPI, indicating that at least four polyphosphate moieties are required for negative staining by DAPI.