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Ab initio pKa calculations suggest that the hydroxyl substituent frequently used for benzamidine moieties may be ionized to form an anionic group, consistent with the general trend.
Presence of such phenolic moieties may be assumed to have synergic effect for the anti-proliferative activities of these bio-adsorbed metal nanoparticles (Kawaii et al. 1999; Salucci et al. 2002; Lee and park 2010).
Surprisingly, the distance between the two indium-DTPA moieties may be quite short and the tyrosyl-lysine dipeptide, substituted by DTPA on both the α-NH2 of tyrosine and the ε-NH2 of lysine, allows for the simultaneous in vitro binding of two anti-DTPA-indium antibodies (Le Doussal et al. 1990).
When using Open Babel for the search purposes (either the fast or the slow mode) it must be taken into account that for some compounds the internal software's representations of the moieties may be different from the strings stored in allcod.smi (hence, not conforming to the conventions indicated in "Format and conventions" section).
Additional imaging moieties may be introduced and coassembled into micelles providing location and biodistribution information about the drug delivery system.
Most bacteria use the products of this reaction for anabolic processes, but at low pH these moieties may be used for cytoplasmic buffering.
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This finding suggests that the ribose moiety may be directly recognized by amino acids from hENT1.
As both compounds were shown to bind to PPARγ, the substitution of the TZD moiety may be beneficial from a drug design perspective.
Thus, we conclude that DHAA dipeptide derivatives containing the sulfonamide moiety may be the potential MMPs inhibitors with the ability to suppress cells migration.
This study thus shows that the incorporation of a 16-methoxycarbonyl coupled with a 21-O-acyl moiety may be a fundamentally sound synthetic strategy in the development of locally active anti-inflammatory steroids having reduced systemic adverse activities.
Considering the higher stability of the Zn II) versus Cu II) complex, it is proposed that this moiety may be of interest to design Zn selective complexing and/or extracting agents.
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