Sentence examples for moieties led to from inspiring English sources

Interestingly, the potency against Escherichia coli strains was unaffected, whereas modification with hydrophobic moieties led to increased activity towards the Gram-negative Acinetobacter baumannii.

The appropriate exploration of the position C-6 with a combination of H-bond acceptor groups coupled with bulky/lipophilic moieties led to the discovery of a new series of mGluR1 antagonists.

Simultaneous coordination of an oxorhenium core by the NS2 and thioethyl moieties led to peptide cyclization and gave the corresponding monomers 13a and b (major isomer) resulting from the syn/anti-isomerism, along with dimers' species 16a and b.

Both the entrapment of a natural zeolite and the presence of carboxylate groups, generated by partial hydrolysis of amide moieties, led to II-CCs with controlled swelling ratios (25 40 g/g, depending on pH) and enhanced overall chelating efficiency (260 mg Cu2+/g composite).

Thus, it was reported that replacement of the carboxylate functionality of 6 with other neutral (e.g., ester, amide) or negatively charged (e.g., acetic acid, phosphate) moieties led to a decrease in antagonist activity.

The intermediate 2 was treated with carbazole substituents and sodium hydride to provide the derivatives 3. Replacement of the carbazole ring by purine (KL005), imidazole (KL006), and phenylindole (KL007) moieties led to the loss of effect of these compounds on the circadian period (Supporting Information Table S1).

Exchange of the coordinating solvents molecules in complex 1 to thiocyanate moieties leads to formation of complex 2 ([C40H56N14Ni(NCS)2](CHCl 3) with an extended parameter D/kB = 8.80 K.

Introduction of a spiro group into the structure of the anthracene moieties lead to a reduction in crystallization tendency, and a high glass transition temperature was observed.

Introduction of a spiro group into the anthracene moieties lead to a reduction in crystallization tendency, and a high glass transition temperature was observed.

Introduction of sulpho-group between the quinoneimine and aryl moieties leads to a considerable increase of electronacceptor properties of compounds under investigation and to decrease of their reduction products nucleophilicity.

Modification of the ester and amino acid moieties lead to a compound INX-08189 that exhibits 10 nM potency in the HCV genotype 1b subgenomic replicon, thus being 500 times more potent than the parent nucleoside.