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Introduction of a spiro group into the structure of the anthracene moieties lead to a reduction in crystallization tendency, and a high glass transition temperature was observed.
Introduction of a spiro group into the anthracene moieties lead to a reduction in crystallization tendency, and a high glass transition temperature was observed.
Modification of the ester and amino acid moieties lead to a compound INX-08189 that exhibits 10 nM potency in the HCV genotype 1b subgenomic replicon, thus being 500 times more potent than the parent nucleoside.
This bend allows the accommodation of bulky substituents in this area of the binding site, whereas more linear moieties lead to a steric clash.
Longer alkyl chains of the xanthate moieties lead to a better mixing of the polymer and nanoparticle phase, to smaller domain sizes and a lower crystallinity of the polymer phase in the P3HT/CdS absorber layers.
This may, in combination with an improved pharmacokinetic profile induced by the PEG and RGD moieties, lead to improved effects of TRAIL in vivo.
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Exchange of the coordinating solvents molecules in complex 1 to thiocyanate moieties leads to formation of complex 2 ([C40H56N14Ni(NCS)2](CHCl 3) with an extended parameter D/kB = 8.80 K.
Interestingly, the potency against Escherichia coli strains was unaffected, whereas modification with hydrophobic moieties led to increased activity towards the Gram-negative Acinetobacter baumannii.
Introduction of sulpho-group between the quinoneimine and aryl moieties leads to a considerable increase of electronacceptor properties of compounds under investigation and to decrease of their reduction products nucleophilicity.
The appropriate exploration of the position C-6 with a combination of H-bond acceptor groups coupled with bulky/lipophilic moieties led to the discovery of a new series of mGluR1 antagonists.
Simultaneous coordination of an oxorhenium core by the NS2 and thioethyl moieties led to peptide cyclization and gave the corresponding monomers 13a and b (major isomer) resulting from the syn/anti-isomerism, along with dimers' species 16a and b.
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