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The blend of three different pharmacologically active moieties into a single scaffold resulted into synergistic effect in their bio-activity.
The assembly of π-conjugated [oligo p-phenylene vinylene)] OPV donors and [oligo p-phenyleneptor moieties into a supramolecular donor–acceptor system is achievinyleneuthenium complexation.
The introduction of 3-arylmethyl, 3-aryloxy and 3-arylthio moieties into a 6-methylsulfonylindole framework using rational drug design led to potent, selective COX-2 inhibitors having efficacy in a rat carrageenan air pouch model.
Azide alkyne click reaction is a convenient way of introducing triazole moieties into a molecule and opens up the possibility to add more functionality by suitable design of azide and alkyne compounds.
Tetrathiafulvalene molecules substituted with a carboxylic acid group (TTFCOOH) were bound as redox-active moieties into a poly(4-vinyl pyridine) (P4VP) skeleton through non-covalent interactions (hydrogen bonds).
IGC reveals that incorporation of ethyl or benzyl moieties into a mesoporous SBA-15 silica framework significantly increases the non-specific dispersive surface energy of adsorption for alkane adsorption, while decreasing the free energy of adsorption of methanol, reflecting increased surface hydrophobicity.
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A novel colorimetric chemosensor (MRN1) was designed and synthesized by incorporating the azobenzene disperse dye-based signalling unit and tridentate chelating moiety into a single molecule.
The use of polyol phosphonyl chlorides or phosphochloridates as phosphorylating agents for cellulose is considered as means of introducing a char-forming centre in association with an acid-generating moiety into a functional polymer which itself is potentially char-forming.
Here we describe incorporation of a vinyl moiety into a peptido sulfonyl fluoride backbone, which should lead to a combined attack of the proteasome active site threonine on the double bond and the sulfonyl fluoride.
Only proline differs from this basic structure as it contains an unusual ring to the N-end amine group, which forces the CO NH amide moiety into a fixed conformation.
1b Clearly, incorporation of the phosphanylidene phosphorane moiety into a suitable cyclic system also renders these systems stable.
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CEO of Professional Science Editing for Scientists @ prosciediting.com