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These compounds bear one or more coordinated cyclopentadienyl moieties connected with a η1-bridging σ-bonded carbon chain featuring a length of at least two carbon atoms.
Novel supramolecular polymer networks PBTH/C and PBTH/F were developed by mixing proper molar amounts of polymer PBTH (containing melamine pendants) to be hydrogen-bonded (H-bonded) with complementary uracil-based conjugated cross-linkers C and F (i.e., containing two symmetrical uracil moieties connected with carbazole and fluorene units through triple bonds).
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Lead structure 1a resulting from the HTS can be characterized by a hydrophobic side chain represented by the phenylpiperazine moiety connected with a catechol moiety via a hydrazone linkage.
Tetracationic multi-uracilophane is composed of two macrocyclic units bridged each other with an external methylene spacer, while in the cryptand-like dicationic uracilophane pyrimidinic moieties are connected with an internal methylene spacer.
The observed HMBC correlations of H-1″/C-5, C-6, C-7; H-6″/C-2′, C-4′, C-4′; and H-7″/C-3′ indicathe the prenyl and 2,2-dimethylpyran moieties were connected with C-6 and C-3′, respectively.
In each cell, one Cz moiety is connected with BTD by vinylene bond in same plane.
Further modification of the monensylamino acids included the lactamization reaction in which the carboxyl group of the corresponding amino acid moiety is connected with monensin O XI)H hydroxyl group.
Both compounds consist of two folded aromatic amide moieties, which are connected with an acetylene linker in 1 or directly in 2. The rigid conformations of their folded moieties are stabilized by intramolecular tri-centered hydrogen bonding, while the whole molecule adopts a 'S'- or 'C'-styled conformation depending on the relative orientation of the two rigid moieties.
Pursuing our recent outcomes regarding the antifungal activity of N-substituted 1,3-thiazolidin-4-ones, we synthesized thirty-six new derivatives introducing aliphatic, cycloaliphatic and heteroaromatic moieties at N1-hydrazine connected with C2 position of the thiazolidinone nucleus and functionalizing the lactam nitrogen with differently substituted (NO2, NH2, Cl and F) benzyl groups.
The design of profen hybrids containing a NO donor moiety connected to an aliphatic spacer led to compounds with a similar cyclooxygenase inhibition compared to their parent profen and with significant antiproliferative activities on PC3 cells.
The AuCl moiety connected to the phosphaalkene of 8 contributes to the HOMO with a d xy orbital localized on the Au and a p orbital localized on the chlorine atom.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com