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We thus designed and synthesized a set of compounds including both a 5-hydroxyindol-3-ylethyl and a 1-arylpiperazine moieties connected by a short linker.
For this reason, binding characteristics were improved by development of the Twin-Strep-tag® consisting of two Strep-tag®II moieties connected by a short linker.
Compound 1 features a 0D {Ni(2,2-bipy)2V2O4(SeO3)2}2 dimeric cluster composed of two {Ni(2,2-bipy)2}2+ moieties connected by the {V4O8(SeO3)4}4- cluster.
Compound 2, incorporating two para-hydroxyphenyl moieties connected by the 1,2,4-oxadiazole ring, was the most active, its potency in inhibiting activation of NF-κB and ROS scavenging abilities surpassing that of resveratrol.
This is not due to the presence of two species, but is attributed to the fact that MTX is composed of two separate chromophoric moieties, connected by an aliphatic –C N– group.
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The compounds were composed by an aromatic function and a tertiary amino moiety connected by a suitable spacer.
In this paper, the design and synthesis of new non-symmetrical monocationic ChoK inhibitors is described, bearing a cationic head and an adenine moiety connected by linkers of different lengths.
This lipophilic molecule has both amyloid-binding and metal-chelating moieties covalently connected by amide bonds.
The two Cu4L1 moieties are connected by four additional CuII ions, giving a polymetallic core that conforms to a tetracapped diamond (or tetracapped square prism).
Donor acceptor moieties connected through π-conjugated bridges i.e. D-π-A, in order to facilitate the electron/charge transfer phenomenon, have wide range of applications.
Novel supramolecular polymer networks PBTH/C and PBTH/F were developed by mixing proper molar amounts of polymer PBTH (containing melamine pendants) to be hydrogen-bonded (H-bonded) with complementary uracil-based conjugated cross-linkers C and F (i.e., containing two symmetrical uracil moieties connected with carbazole and fluorene units through triple bonds).
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