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Sugar moieties are known to improve the pharmacokinetic properties and/or affect the biological activity of glycosides in important natural pharmaceutical products (Weymouth-Wilson 1997).
The catechol moieties are known to have the properties of charge-transfer complex formation between the catechol groups and Ti4+ [35,36].
A specific feature of the Zn-CDFs is the presence of few cysteine residues conserved within some clusters: sulfhydryl moieties are known to have a role in metal binding (mostly Zn2+ and Cd2+).
In an approach to increase selectivity, we attached melamine and benzamidine motifs to the quinols, because these moieties are known to be selectively concentrated in the parasite by transporter proteins.
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Many compounds with this structural moiety are known to be mutagenic [20].
The macrolide antibiotics oligomycin, venturicidin and bafilomycin, sharing the polyketide ring and differing in the deoxysugar moiety, are known to block the transmembrane ion channel of ion-pumping ATPases; oligomycins are selective inhibitors of mitochondrial ATP synthases.
Owing to thioether diverse physicochemical properties by non-covalent interactions with bio-macromolecules, thioether derivatives containing heterocyclic moiety are known for their interesting insecticidal bioactivities and attracting considerable attention as neuroactive insecticides.
Alkaline phosphatases (ALPs), typically anchored by GPI-moieties, are known to be Cry toxin receptors in Lepidoptera [ 38, 39] and mosquitoes [ 36, 40].
The C-terminal moiety is known to play critical roles in regulating bone and dentine development, while the N-terminal facilitates osteogenesis (Sun, et al., 2015).
Although the SH moiety is known to play a critical role in the reduction of Au3+ species, the carboxylic acid (COOH) group could spontaneously reduce aqueous chloroaurate ions leading to the formation of Au nanoparticles [29].
The finding that TFV persisted up to 181 hours post-gel application could reflect the prolonged half-life of extracellular drug in the vaginal lumen and/or transport of dephosphorylated drug from intracellular stores (where the phosphorylated moiety is known to have a prolonged half-life) back into the extracellular space of the cervicovaginal tissue or lumen.
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