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The cinnamate and vanillate moieties are derived from PP pathway.
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The targeting moiety was derived from the modular domain present in αL integrin, which was engineered for high affinity and cross-reactivity with human and murine ICAM-1.
The understanding of capping of biological moiety is derived from Fourier transform infrared spectroscopy and the thermo gravimetric analysis [14].
The parameters of the sulfoxide moiety were derived based on previous work [44], [45].
Iridoid moiety is derived from geranyl pyrophosphate (GPP).
The acetyl moiety is derived either from glycolysis or fatty acid oxidation.
47 The alkyl moiety is derived from fatty alcohols that are chiefly 16- to 18-carbons long (Fig. 3 ).
In E. coli, the thiazole moiety is derived from condensation of tyrosine, cysteine, and 1-deoxy d-xylulose-5-phosphate (Du et al. 2011), which involves thiazole synthase ThiH, which is not identifiable in the P. carbekii genome (including all plasmids).
The reaction scheme is depicted in Figure 3. From the reaction stoichiometries two moiety conservations are derived: NAD + NADH = const; ATP + ADP + AMP = const.
The d-glucuronic acid (GlcUA) and N-acetyl glucosamine (GlcNAc) moieties of HA are derived from glucose-6-phosphate and fructose-6-phosphate, respectively (Chong and Nielsen 2003).
However, we have yet to distinguish which H-cluster non-protein moieties, if any, are derived from tyrosine.
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