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Deglycosylation demonstrated that sugar moieties are critical for maintaining solubility of FGL2.
Controlling fatty acid and alcohol moieties are critical to produce designer biodiesels with desirable physiochemical properties (e.g., high cetane number, low kinematic viscosity, high oxidative stability, and low cloud point).
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The spatial distribution of these moieties is critical for the intended function of the particular nanoparticle.
These results suggest that, as in humans (11, 15 ), attachment of influenza virus to the proximal part of the respiratory tract, which depends largely on appropriate sialic acid moieties, is critical for susceptibility and efficient transmission of influenza viruses in marine mammals.
To determine which chemical group or moiety is critical for the neurotrophic activity of gedunin, we have conducted a structure-activity relationship study.
We show that the lgtB moiety is critical for internalization of NOMV by DC.
Indeed, the folate recognition moiety was critical for cellular uptake of this biosensor.
The above crystal structures, simulations and mutagenesis studies strongly suggested that the hydrogen bonding network with the hydantoin moiety is critical for binding.
To support this idea, some researchers have suggested that the quinone methide moiety is critical to celastrol's cytotoxic and apoptotic activity, while the acidic carboxylate group is important to heat shock response and cytoprotective activity [ 6].
We hypothesized that the para-hydroquinone moiety was critical for this activation because it enhanced transcription of these neuroprotective pathways to a greater degree than that of the corresponding ortho-hydroquinone isomer.
An investigation of the structures and physical properties of the surfactants can suggest which surfactant moieties are most critical in aiding TM protein digestion.
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