The core of ertapenem, comprising the pyrroline, carboxylate, and hydroxyethyl moieties, is anchored by a total of eight hydrogen bonds to the surrounding protein molecule.
In another reported method [10] of nanoparticle stabilization, the silane moiety is anchored first, which is followed by a second step involving the reaction with the ATRP initiator, which is a heterogeneous reaction.
The ribosyl moiety is anchored via hydrogen bonds with the C-2 hydroxyl group of the side chain of Tyr22.
Waters form cages around hydrophobic moieties and these cages are anchored by hydrogen bonding to nearby hydrophilic groups.
Some proteins are anchored by lipid moieties added as a posttranslational modification.
Four MT-MMPs (MT1- to MT4-MMPs) are anchored to the cell membrane through a type I TM domain while the other two MT-MMPs (MT5- and MT6-MMPs) are tethered to the membrane via a GPI moiety.
Using the PAD method, the tetrahedrally coordinated Cr-oxide moieties can be anchored on Ti-HMS forming the direct interaction between Cr-oxide and Ti-oxide moieties.
The phosphate moiety of PLP is anchored by polar interactions with the peptide amide groups of residues A148 and S149 as well as by the side chains of S149, N299, and two water molecules.
LPS consists of a lipid A moiety, by which LPS is anchored to the membrane, a core oligosaccharide, which extends outward from the membrane, and a distal O-specific polysaccharide chain (O antigen) (Raetz and Whitfield, 2002).
Furthermore, the hydroxy group of the tyrosine moiety of the inhibitor is anchored via water-mediated hydrogen bonds with Asp, His and Lys.
